Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

Current antimicrobial drug discovery and advancement attempts are aimed to identify new complexes that can work effectively against the infections caused by microbes. The aim of present study was synthesize diorganotin(IV) N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-2-nitrobenzohydrazide (H2L1), N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-3-methoxybenzohydrazide (H2L2) N'-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-4-methylbenzohydrazide (H2L3) Schiff base ligands with formula R2SnL1?3 (where R = Me, Et, Bu Ph). Various spectral physico-analytical techniques such as elemental analysis, FT-IR, multinuclear (1H, 13C, 119Sn) NMR, HRMS XRD were utilized structurally elucidate prepared compounds. Based on data, it concluded behave in a tridentate manner coordinates central tin atom through ONO donor atoms. Furthermore, synthesized compounds examined for vitro activity four bacterial two fungal strains. Among compounds, Ph2SnL1 complex (MIC 0.0095 µmol/mL) found be most active. To rationalize preferred mode interactions active compound, molecular docking compound executed binding site 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) E. coli sterol 14-alpha demethylase C. albicans. Compound inhibits microbes could an effective candidate modulation various infections. New (4–15) from hydrazones (1–3). activity. Further, potent (7) performed enzyme